ORAL SESSION 5: Endometriosis Biology, Pain, Fertility, and Long-Term Risk

Monday, November 16, 2026
10:30 am - 11:30 am

Room: RM306

Faculty: Natassia M. Dunn, Adeline Y. Chin, Richard Hsu, Assia A. Stepanian, Siddhi Mathur, Waldir Inacio Jr., Gil Dubernard

Description: This session explores endometriosis beyond the operating room by examining molecular biology, pain phenotyping, comorbidities, fertility impact, diagnosis timing, cancer risk, and financial

Learning Objectives: At the end of this course, the participant will be able to:

1. Describe emerging molecular and translational insights in endometriosis.
2. Assess how pain, comorbidities, and financial toxicity shape patient outcomes.
3. Evaluate fertility and long-term health implications of endometriosis diagnosis and treatment.

Course Outline

10:30 AM Welcome, Introduction and Course Overview

10:32 AM Molecular Insights Into Endometriosis: A Study of Gene Expression

J. Borgerding, N. Dunn, J. Lang, N. Yask, Z. Chen, T. Kalir, T. Martin, A. Horowitz, C. Ascher-Walsh, S. Kim-Schulze, S. Khalil

10:38 AM The Hidden Burden: Connective Tissue, Mast Cell, and Autoimmune Comorbidities Cluster in Pots With Endometriosis

A. Chin, R. Rilinger, P. Leboit, M. Levine, A. Nowacki, A. Brant, C. Cameron, A. Gubbels, R. Wilson

10:44 AM Cost-Effectiveness of Early Versus Delayed Endometriosis Diagnosis: A Markov Decision Model Analysis

R. Hsu, E. Han, E. Banks, K. Denny

10:50 AM Somatic Mutations in Endometriosis Lesions and Endometrium: Narrative Review

L. Adamyan, L. Pivazyan, K. Mailova, M. Kuznetsova, D. Trofimov, A. Stepanian

10:56 AM Are Patients With Endometriosis at an Increased Risk for Gynecologic Malignancy?

S. Mathur, R. Sutradhar, N. Baxter, N. Liu, N. Sule, O. Bougie, G. Bouchard-Fortier, A. Simpson

11:02 AM The Cost of Care: Financial Toxicity Among Patients With Endometriosis

A. Lalla, C. Bald, E. Pobezinskaya, E. Jorgensen

11:08 AM Effect of Laparoscopic Surgical Treatment of Endometriosis on Spontaneous Pregnancy Outcomes in Infertile Women: A Meta-Analysis

W. Inacio, M. Lemos, S. Leite, E. Rodrigues, Y. Youssef, C. King

11:14 AM HIFU Treatment of Rectal Endometriosis: Short- and Long-Term Results of a Double-Blind Randomised Trial Versus Sham Procedures

G. Dubernard

11:20 AM Discussion Questions & Answers

11:30 AM Adjourn